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Caption | Ptentm2Mak/Ptentm2Mak Stk11tm1Keis/Stk11tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 (Pten/Lkb1fl/fl) mouse urothelium undergoes epithelial-mesenchymal transition (EMT). Mouse bladder epithelium deficient for both Stk11 (Lkb1) and Pten exhibits loss in epithelial markers and acquire mesenchymal properties by day 100. Rapamycin inhibition of mTOR suppresses the observed effect. A, E-cadherin and ZO-1 immunofluorescent co-localization showing disappearance of these proteins from cell-cell walls in double mutant bladder whereas rapamycin treatment prevents this loss, B, Immunostaining showing a strong increase in Vimentin levels and Snail nuclear localisation after the combined deletion of Stk11 and Pten and this is mediated via mTOR evidenced from their suppressed levels in rapamycin-treated animals. Scale bars correspond to 20 um. | ||||||||
Copyright | This image is from Shorning BY, PLoS One 2011;6(1):e16209, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:169565 | ||||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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