Phenotype Image Detail

Image

Caption

Cauda-retrieved spermatozoa of Gpx5^tm1115.2Arte/Gpx5^tm1115.2Arte (KO) animals suffer oxidative damages. (A) Immunodetection of the nuclear adduct 8-oxodG in cauda epididymidis-retrieved spermatozoa preparations from 6-month-old wild-type (WT), KO, or hydrogen perioxide-treated WT male mice. Images are representative of several distinct detections. (B) Histograms showing the percentage of 8-oxodG-positive spermatozoa in cauda epididymidis-retrieved spermatozoa preparations, from 6-month-old WT, KO, and positive control (WT spermatozoa treated with hydrogen peroxide) male mice. Data are mean SEM. n = 3. **P < 0.05.

Copyright

This image is from Chabory E, J Clin Invest 2009 Jul;119(7):2074-85 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152563

Associated Alleles

Symbol	Name
Gpx5^tm1115.2Arte	glutathione peroxidase 5; targeted mutation 1115.2, TaconicArtemis

Associated Genotypes

Allelic Composition	Genetic Background
Gpx5^tm1115.2Arte/Gpx5^tm1115.2Arte	involves: C57BL/6 * C57BL/6N