Phenotype Image Detail

Image

Caption

The cauda epididymidis epithelium of Gpx5^tm1115.2Arte/Gpx5^tm1115.2Arte (Gpx5-/-) animals suffers from oxidative damage. (A) Detection of the nuclear 8-oxodG modification in cauda epididymidis epithelium sections of 14-month-old wild-type (WT) and mutant male mice. Note the strong and uniform nuclear labeling in the mutant section. L, lumen; E, epithelium; ITS, intertubular space. (B) Malondialdehyde (MDA) measurements on cauda-collected spermatozoa samples from 6-month-old WT and mutant animals. Data are mean +/- SEM.

Copyright

This image is from Chabory E, J Clin Invest 2009 Jul;119(7):2074-85 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152563

Associated Alleles

Symbol	Name
Gpx5^tm1115.2Arte	glutathione peroxidase 5; targeted mutation 1115.2, TaconicArtemis

Associated Genotypes

Allelic Composition	Genetic Background
Gpx5^tm1115.2Arte/Gpx5^tm1115.2Arte	involves: C57BL/6 * C57BL/6N