Phenotype Image Detail

Image

Caption

A thin cornea (black arrows in A) and iridocorneal dysgenesis (black arrowheads in B) were observed in the Ext1^tm1Yama/Ext1⁺ H2az2^{Tg(Wnt1-cre)11Rth}/0 Tgfb2^tm1Doe/Tgfb2⁺ mutants at E18.5.

Copyright

This image is from Iwao K, J Clin Invest 2009 Jul;119(7):1997-2008 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152572

Associated Alleles

Symbol	Name
Ext1^tm1Yama	exostosin glycosyltransferase 1; targeted mutation 1, Yu Yamaguchi
H2az2^Tg(Wnt1-cre)11Rth	H2A.Z histone variant 2; transgene insertion 11, David H Rowitch
Tgfb2^tm1Doe	transforming growth factor, beta 2; targeted mutation 1, Thomas Doetschman

Associated Genotypes

Allelic Composition	Genetic Background
Ext1^tm1Yama/Ext1^+ H2az2^Tg(Wnt1-cre)11Rth/H2az2^+ Tgfb2^tm1Doe/Tgfb2^+	B6.Cg-Tgfb2^tm1Doe H2az2^Tg(Wnt1-cre)11Rth Ext1^tm1Yama