Phenotype Image Detail

Image

Caption

Aberrant iridocorneal development in Ext1^tm1Yama/Ext1⁺ H2az2^{Tg(Wnt1-cre)11Rth}/0 Tgfb2^tm1Doe/Tgfb2⁺ mice. (A) There were no major anomalies noted in Schlemm canal (black arrows) or the trabecular beam (white arrowheads) for either the controls (A) or the Ext1 (B) or Tgfb2 (C) haploinsufficient mutants. As compared with the wild-type mice, the double heterozygous mice (D) had a hypoplastic trabecular beam, and they lacked a Schlemm canal. The double heterozygous mice also exhibited a significant reduction of the total cell number for the iridocorneal angle.

Copyright

This image is from Iwao K, J Clin Invest 2009 Jul;119(7):1997-2008 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152572

Associated Alleles

Symbol	Name
Ext1^tm1Yama	exostosin glycosyltransferase 1; targeted mutation 1, Yu Yamaguchi
H2az2^Tg(Wnt1-cre)11Rth	H2A.Z histone variant 2; transgene insertion 11, David H Rowitch
Tgfb2^tm1Doe	transforming growth factor, beta 2; targeted mutation 1, Thomas Doetschman

Associated Genotypes

Allelic Composition	Genetic Background
Ext1^tm1Yama/Ext1^+ H2az2^Tg(Wnt1-cre)11Rth/H2az2^+ Tgfb2^tm1Doe/Tgfb2^+	B6.Cg-Tgfb2^tm1Doe H2az2^Tg(Wnt1-cre)11Rth Ext1^tm1Yama