Phenotype Image Detail

Image

Caption

Normal neuromuscular junction (NMJ) formation but increased nerve branching in Stac3^{tm1a(KOMP)Wtsi}/Stac3^{tm1a(KOMP)Wtsi} (KO) mice. Whole mounts of E18.5 diaphragm muscles were double-stained with Texas red alpha-bungarotoxin to label postsynaptic AChRs and an antibody against syntaxin to label presynaptic nerves. In both wild-type (WT) and mutant muscles, presynaptic nerve terminals formed in juxtaposition with postsynaptic AChR clusters (B). However, there were increased nerve branching and defasciculation in the mutant diaphragm compared with the WT (A). AChR clusters also occupied a broader area in the central region of the KO diaphragm. [Scale bars, 400 um (A), 20 um (B).]

Copyright

This image is from Nelson BR, Proc Natl Acad Sci U S A 2013 Jul 16;110(29):11881-6. Copyright 2013 National Academy of Sciences, U.S.A. J:222015

Associated Alleles

Symbol	Name
Stac3^tm1a(KOMP)Wtsi	SH3 and cysteine rich domain 3; targeted mutation 1a, Wellcome Trust Sanger Institute
Stac3^tm1a(KOMP)Wtsi	SH3 and cysteine rich domain 3; targeted mutation 1a, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Stac3^tm1a(KOMP)Wtsi/Stac3^tm1a(KOMP)Wtsi	involves: C57BL/6N