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Caption | Normal neuromuscular junction (NMJ) formation but increased nerve branching in Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi (KO) mice. Whole mounts of E18.5 diaphragm muscles were double-stained with Texas red alpha-bungarotoxin to label postsynaptic AChRs and an antibody against syntaxin to label presynaptic nerves. In both wild-type (WT) and mutant muscles, presynaptic nerve terminals formed in juxtaposition with postsynaptic AChR clusters (B). However, there were increased nerve branching and defasciculation in the mutant diaphragm compared with the WT (A). AChR clusters also occupied a broader area in the central region of the KO diaphragm. [Scale bars, 400 um (A), 20 um (B).] | ||||||
Copyright | This image is from Nelson BR, Proc Natl Acad Sci U S A 2013 Jul 16;110(29):11881-6. Copyright 2013 National Academy of Sciences, U.S.A. J:222015 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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