Phenotype Image Detail

Image

Caption

Delayed retinal angiogenesis during early postnatal stages in Elk3^tm1.2Ics/Elk3^tm1.2Ics [Elk3(-/-)] mice. (A) IsolectinB4 staining of flat-mounts of retinae from P4 wild-type (WT) and mutant mice. The red lines outline the whole retinal area, the yellow lines the areas covered by blood vessels. (B) Quantitation of retinal area covered by blood vessels (% vascularization) at P4. (C) Higher magnification of the angiogenic front in P4 control and mutant knockout retinae. (D) IsolectinB4 staining of retinal flat-mounts of a P6 WT and mutant mouse. The red arrow points towards delayed angiogenic front in the mutant retina. (E) Quantitation of retinal area covered by blood vessels (% vascularization) at P6. (F) Higher magnification of the angiogenic front in P6 control and mutant retinae. (G) IsolectinB4 staining of retinal flat-mounts from P8 WT and mutant mice. The red arrow points towards the delayed angiogenic front in the mutant retina. (H) Quantitation of retinal area covered by blood vessels (% vascularization) at P8. (I) Higher magnification of the angiogenic front in P8 control and mutant retinae. All quantitation data are normalized to the control = 100%. The data shown are means +/- s.e.m. Statistical significance using Student's t-test is indicated with * p<0.05 ** p<0.01 *** p<0.001. Scale bar in (A, D, G) 1000 um, in (C, F, I) 100 um.

Copyright

This image is from Weinl C, PLoS One 2014;9(9):e107048, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:221521

Associated Alleles

Symbol	Name
Elk3^tm1.2Ics	ELK3, member of ETS oncogene family; targeted mutation 1.2, Mouse Clinical Institute

Associated Genotypes

Allelic Composition	Genetic Background
Elk3^tm1.2Ics/Elk3^tm1.2Ics	involves: 129S2/SvPas * C57BL/6J