Phenotype Image Detail

Image

Caption

Scanning laser ophthalmoscopy reveals abnormally shaped tortuous arteries in adult Elk3^tm1.2Ics/Elk3^tm1.2Ics [(Elk3(-/-)] eyes. (A) Scanning laser ophthalmoscopy (SLO) of wild-type (WT, upper panel) and mutant knockout (lower panel) retinae by indocyanin green angiography (left) and a higher magnification of arteries in IsolectinB4 stained retinal flat-mounts of the same retina (middle; tortuous arteries are highlighted by red arrowheads). H&E staining of paraffin embedded whole eyes (right).

Copyright

This image is from Weinl C, PLoS One 2014;9(9):e107048, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:221521

Associated Alleles

Symbol	Name
Elk3^tm1.2Ics	ELK3, member of ETS oncogene family; targeted mutation 1.2, Mouse Clinical Institute

Associated Genotypes

Allelic Composition	Genetic Background
Elk3^tm1.2Ics/Elk3^tm1.2Ics	involves: 129S2/SvPas * C57BL/6J