Phenotype Image Detail

Image

Caption

Disruption of Spg11 decreases the regeneration of lysosomes in Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} mouse embryonic fibroblasts (MEFs). Upon 6 hours of starvation, lysosomes were depleted in both wild-type (WT) and Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} (KO) MEFs. After 14 hours, lysosome numbers recovered to baseline levels only in WT. Mean +/- SEM of n = 3 experiments; Student's t-test: * indicates p<0.05). Scale bars: 10 um.

Copyright

This image is from Varga RE, PLoS Genet 2015 Aug;11(8):e1005454, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:228803

Associated Alleles

Symbol	Name
Spg11^Gt(EUCE0085f05)Hmgu	SPG11, spatacsin vesicle trafficking associated; gene trap EUCE0085f05, Helmholtz Zentrum Muenchen GmbH

Associated Genotypes

Allelic Composition	Genetic Background
Spg11^Gt(EUCE0085f05)Hmgu/Spg11^Gt(EUCE0085f05)Hmgu	involves: 129P2/OlaHsd * C57BL/6