Phenotype Image Detail

Image

Caption

(C, D) The ultrastructural analysis of Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} (KO) Purkinje cells reveals clusters of vesicular structures filled with autophagic material (arrows) and irregularly shaped electron-dense lipofuscin-like deposits (D, arrowhead), while only some lipofuscin particles are found in wild-type (WT) (C, arrowheads). Scale bars: 2 um. (F-G") Lysosomes defined as vesicles positive for Lamp1 but negative for p62 are decreased in Purkinje cells of 2-month-old and 11-month-old (displayed in F-G") mutant mice (Mean SEM; n = 3 experiments; One-way ANOVA: * indicates p<0.05; ** indicates p<0.005). Scale bar: 10 um.

Copyright

This image is from Varga RE, PLoS Genet 2015 Aug;11(8):e1005454, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:228803

Associated Alleles

Symbol	Name
Spg11^Gt(EUCE0085f05)Hmgu	SPG11, spatacsin vesicle trafficking associated; gene trap EUCE0085f05, Helmholtz Zentrum Muenchen GmbH

Associated Genotypes

Allelic Composition	Genetic Background
Spg11^Gt(EUCE0085f05)Hmgu/Spg11^Gt(EUCE0085f05)Hmgu	involves: 129P2/OlaHsd * C57BL/6