Phenotype Image Detail

Image

Caption

Autolysosomes and lipofuscin-like material in different brain regions of Spg11^{Gt(EUCE0085f05)Hmgu}/Spg11^{Gt(EUCE0085f05)Hmgu} (KO) mice. (A-C) Compared to wild-type (WT) the ultrastructural analysis of cortical neurons in 16-month-old mutant mice reveals large clusters of irregularly shaped electron-dense lipofuscin-like deposits (B, arrowheads) and membranous structures filled with autophagic material (C, arrows). (D, E) In hippocampal pyramidal neurons of 16-month-old mutant (E) mice the accumulation of lipofuscin-like material is quite prominent compared to WT (D). (F) Axonal swelling filled with autophagic vesicles in the corticospinal tract of 16-month-old KO mouse. Scale bars: 2 um (A, B, D, E), 0.5 um (C,F).

Copyright

This image is from Varga RE, PLoS Genet 2015 Aug;11(8):e1005454, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:228803

Associated Alleles

Symbol	Name
Spg11^Gt(EUCE0085f05)Hmgu	SPG11, spatacsin vesicle trafficking associated; gene trap EUCE0085f05, Helmholtz Zentrum Muenchen GmbH

Associated Genotypes

Allelic Composition	Genetic Background
Spg11^Gt(EUCE0085f05)Hmgu/Spg11^Gt(EUCE0085f05)Hmgu	involves: 129P2/OlaHsd * C57BL/6