Phenotype Image Detail

Image

Caption

Hypoplastic and glomerulocystic kidneys in Arhgap35^m1Bchd/Arhgap35^m1Bchd (Arhgap35^-/-) mutants. (D-E) Whole urogenital systems dissected at E17.5. In contrast to normal sized kidneys in control animals (panel D), Arhgap35^m1Bchd/Arhgap35^m1Bchd (E) kidneys exhibit hypoplasia (arrows) or agenesis (arrowheads). (J-K) Hematoxylin and Eosin stained sections (20X) show large glomerular cysts (asterisks), accompanied by occasional proximal tubule (PT) dilation in the mutant animals (K). (J'-K') Higher magnification (63x) images show that glomerular architecture is largely preserved in cystic glomeruli. Scale bars, 20um . *p<0.05, **p<0.01, ***p<0.005, ****p<0.001 (one-way ANOVA).

Copyright

This image is from Stewart K, PLoS Genet 2016 Feb;12(2):e1005785, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:232342

Associated Alleles

Symbol	Name
Arhgap35^tm1Jset	Rho GTPase activating protein 35; targeted mutation 1, Jeffrey Settleman

Associated Genotypes

Allelic Composition	Genetic Background
Arhgap35^tm1Jset/Arhgap35^tm1Jset	involves: 129S2/SvPas