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Phenotype Image Detail
Image
Caption Smad4tm1.1Gsu/Smad4tm1.1Gsu Ptf1atm1.1(cre)Cvw/Ptf1a+ Tg(MtTGFA)Lmb/0 (STP) mice displayed molecular signatures of human chronic pancreatitis. Significantly elevated Mucin-6 expression was detected in the STP mice. (A) Immunohistochemistry (IHC) analysis of Mucin-6 expression in the pancreata from Tg(MtTGFA)Lmb/0 (MT-TGFalpha) (panel i) and STP mice (panel ii) treated with zinc sulfate for 8 months. Elevated expression of Mucin-6 was detected in evolving acinar-to-ductal metaplasia (ADM) and PanIN lesions of the STP mice. Magnification panels i and ii, 200x.
Copyright This image is from Garcia-Carracedo D, PLoS One 2015;10(3):e0120851, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:229184
Associated
Alleles
Symbol Name
Ptf1atm1.1(cre)Cvw pancreas specific transcription factor, 1a; targeted mutation 1.1, Christopher VE Wright
Smad4tm1.1Gsu SMAD family member 4; targeted mutation 1.1, Gloria H Su
Tg(MtTGFA)Lmb transgene insertion, Glenn Merlino
Associated
Genotypes
Allelic Composition Genetic Background
Smad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MtTGFA)Lmb/0
involves: 129S1/Sv * 129X1/SvJ * CD-1
Tg(MtTGFA)Lmb/0 involves: CD-1

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory