Phenotype Image Detail

Image

Caption

Commd9^{Gt(AQ0362)Wtsi}/Commd9^{Gt(AQ0362)Wtsi} (KO) embryos display neural tube edema (white arrows), seen by E10.5 (left). This is followed by punctate hemorrhages (yellow arrows), seen at E11.5 (right). WT, wild-type. Bar, 500 um. (C) Mutant embryos eventually developed widespread hemorrhages that are apparent by E11.5 and at later stages. Bar, 500 um. (D) Cross-sectional histologic analysis demonstrated small hypoplastic hearts in all the mutant embryos. Bar, 200 um. (E) Areas of unilateral narrowing of the dorsal aorta were commonly seen in mutant embryos (arrow). Bar, 100 um.

Copyright

This image is from Li H, J Cell Biol 2015 Nov 9;211(3):605-17, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:230747

Associated Alleles

Symbol	Name
Commd9^Gt(AQ0362)Wtsi	COMM domain containing 9; gene trap AQ0362, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Commd9^Gt(AQ0362)Wtsi/Commd9^Gt(AQ0362)Wtsi	involves: 129P2/OlaHsd