Phenotype Image Detail

Image

Caption

Myocardial wall necrosis and pericardial bleeding (arrow) was observed in Commd9^{Gt(AQ0362)Wtsi}/Commd9^{Gt(AQ0362)Wtsi} (K/O) embryos. Bar, 40 um. (G) Pecam1 immunohistochemistry staining in mutant embryos demonstrated significant reduction of truncal vessels in the embryo head that connect to distal capillary networks compared with wild-type (WT) (arrow). Bar, 100 mm. (H) In situ hybridization with a Cx40 probe indicates normal cephalic arterial vessels in mutant embryos (left, E10.5), whereas in situ hybridization for Apj showed significant changes in the venous vasculature with ectatic dilations noted in the mutant embryos (right, E11.5). Bar, 100 mm.

Copyright

This image is from Li H, J Cell Biol 2015 Nov 9;211(3):605-17, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:230747

Associated Alleles

Symbol	Name
Commd9^Gt(AQ0362)Wtsi	COMM domain containing 9; gene trap AQ0362, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Commd9^Gt(AQ0362)Wtsi/Commd9^Gt(AQ0362)Wtsi	involves: 129P2/OlaHsd