Phenotype Image Detail

Image

Caption

Skeletal abnormalities in Rps7^Zma/Rps7⁺ mutants.(A, B) Comparative X-rays of adult wild-type (WT) (A) and mutant (B) mice show severe vertebral fusion leading to tail kinking in the mutant. (C-H) Alcian blue and alizarin red skeletal staining of late gestation WT (C, E, G) and heterozygous mutant (D, F, H) embryos. (C, D) Disorganization within the neural arches of the mutant is evident in a dorsal view of the cervical vertebrae. (E, F) Asymmetric attachment of 8 ribs to the sternum (arrow) and a shortened first sternebrae (*) are indicated in the mutant. (G, H) Delayed development and disorganization of the ossification centers is apparent in the lumbar and sacral vertebrae. The sacral vertebrae show abnormal fusing of additional vertebrae (bracketed region). Scale bars: C,D,G,H = 2 mm; E,F = 200 um.

Copyright

This image is from Watkins-Chow DE, PLoS Genet 2013 Jan;9(1):e1003094, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195156

Associated Alleles

Symbol	Name
Rps7^Zma	ribosomal protein S7; zuma

Associated Genotypes

Allelic Composition	Genetic Background
Rps7^Zma/Rps7^+	involves: BALB/c * C3H/HeH * C57BL/6J