Phenotype Image Detail

Image

Caption

Brain size and behavioral abnormalities in Rps7^Mtu/Rps7⁺ (Mtu/+) and Rps7^Zma/Rps7⁺ (Zma/+)) mutants. (A) A Nissl stained coronal section of a 5 month old Rps7^Mtu/Rps7⁺ brain shows a thinner cortex and larger ventricles when compared to a wild-type (+/+) littermate. (B, C) Dissected whole brains show that the cortex is reduced in size in adult Rps7^Mtu/Rps7⁺ (B) and postnatal day 0 Rps7^Zma/Rps7⁺ mice (C) when compared to WT littermates. (D-I) Magnetic Resonance Microscopy (MRM) was used to visualize brain development in late gestation (E18.5) WT (D-F) and Rps7^Zma/Rps7⁺ (G-I) embryos. Enlarged ventricles (v in panel H) were apparent in all Rps7^Zma/Rps7⁺ samples (N = 3). Representative slices are shown in sagittal (D,G), coronal (E,H), and axial (F,I) views. Scale bars = 1 mm.

Copyright

This image is from Watkins-Chow DE, PLoS Genet 2013 Jan;9(1):e1003094, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195156

Associated Alleles

Symbol	Name
Rps7^Mtu	ribosomal protein S7; montu
Rps7^Zma	ribosomal protein S7; zuma

Associated Genotypes

Allelic Composition	Genetic Background
Rps7^Mtu/Rps7^+	involves: BALB/cOlaHsd * C3H/HeH
Rps7^Zma/Rps7^+	involves: BALB/c * C3H/HeH * C57BL/6J