Phenotype Image Detail

Image

Caption

Increased apoptosis occurs in the developing central nervous system (CNS) of Rps7^Zma/Rps7⁺ (Z/+) mutant embryos; however, this apoptosis is reduced in Rps7^Zma/Rps7⁺ Trp53^tm1Tyj/Trp53⁺ (Z/+;p53/+) embryos. (A-C) Increased apoptosis was observed in E11.5 Rps7^Zma/Rps7⁺ coronal sections through the neocortex compared to wild-type (+/+) and Rps7^Zma/Rps7⁺ Trp53^tm1Tyj/Trp53⁺, as measured by cleaved caspase-3 (CC3) staining shown in green. (D-F) Apoptosis was also relatively increased in neural tube cross-sections of Rps7^Zma/Rps7⁺ embryos at E11.5 (E). (G-I) Cellular disorganization was apparent in mitotic, phosphohistone H3-positive (PH3+) cells surrounding the lumen of the neural tube in E11.5 Rps7^Zma/Rps7⁺ embryos (H).

Copyright

This image is from Watkins-Chow DE, PLoS Genet 2013 Jan;9(1):e1003094, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195156

Associated Alleles

Symbol	Name
Rps7^Zma	ribosomal protein S7; zuma
Trp53^tm1Tyj	transformation related protein 53; targeted mutation 1, Tyler Jacks

Associated Genotypes

Allelic Composition	Genetic Background
Rps7^Zma/Rps7^+	involves: BALB/c * C3H/HeH * C57BL/6J
Rps7^Zma/Rps7^+ Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * BALB/c * C3H/HeH * C57BL/6J