Phenotype Image Detail

Image

Caption

Embryonic developmental delay in Rps7^Zma/Rps7⁺ (Rps7^Zma/⁺) mice is suppressed by Trp53 deficiency. Chronologically age-matched littermate embryos illustrate that Rps7^Zma/Rps7⁺ mice exhibit developmental delay at E11.5 and E12.5 relative to wild-type (Rps7^+/+) littermates (left 4 panels). This Rps7^Zma-associated developmental delay is suppressed by Trp53 deficiency in Rps7^Zma/Rps7⁺ Trp53^tm1Tyj/Trp53⁺ (Rps7^Zma/⁺; Trp53^KO/+) (right 4 panels). Images for each of the 4 genotypes are shown at the same magnification within an age (row).

Copyright

This image is from Watkins-Chow DE, PLoS Genet 2013 Jan;9(1):e1003094, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195156

Associated Alleles

Symbol	Name
Rps7^Zma	ribosomal protein S7; zuma
Trp53^tm1Tyj	transformation related protein 53; targeted mutation 1, Tyler Jacks

Associated Genotypes

Allelic Composition	Genetic Background
Rps7^Zma/Rps7^+	involves: BALB/c * C3H/HeH * C57BL/6J
Rps7^Zma/Rps7^+ Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * BALB/c * C3H/HeH * C57BL/6J