Phenotype Image Detail

Image

Caption

Mutation of Rps7 and Sox10 act synergistically to reduce melanoblast number. Rps7^Zma/Rps7⁺ Sox10^tm1Weg/Sox10⁺ (Rps7^Zma/+; Sox10^LacZ/+) embryos show greatly reduced melanoblast number at E12.5 (middle 3 panels) as compared to E12.5 Sox10^tm1Weg/Sox10⁺ (Rps7^+/+;Sox10^LacZ/+) mice (left 3 panels). Furthermore, E12.5 double heterozygous mice showed a greater reduction in melanoblast number in comparison with E11.5 single Sox10^tm1Weg/Sox10⁺ mice, indicating that this reduction in melanoblasts exceeded the gross developmental delay observed in Rps7^Zma/Rps7⁺ mutants. Reduction is especially evident in melanoblast populations in the otic area (arrow), and in the tail region posterior to the hindlimb (arrowhead and posterior). Scale bars = 1 mm.

Copyright

This image is from Watkins-Chow DE, PLoS Genet 2013 Jan;9(1):e1003094, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195156

Associated Alleles

Symbol	Name
Rps7^Zma	ribosomal protein S7; zuma
Sox10^tm1Weg	SRY (sex determining region Y)-box 10; targeted mutation 1, Michael Wegner

Associated Genotypes

Allelic Composition	Genetic Background
Rps7^Zma/Rps7^+ Sox10^tm1Weg/Sox10^+	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeH