Phenotype Image Detail

Image

Caption

Rps7 mutation increases Sox10-dependent hypopigmentation and does not result in dark skin. (A, B) Rps7^Zma/Rps7⁺ Sox10^tm1Weg/Sox10⁺ (Sox10^LacZ/+;Rps7^Zma/+) mutants that survive postnatally exhibit more extensive hypopigmentation than the single Rps7^Zma/Rps7⁺ or Sox10^tm1Weg/Sox10⁺ mutants. A representative double mutant mouse is shown along with quantitative scoring (0 = no spotting; 4 = the largest ventral spots that extend to the dorsal surface) comparing the white spotting in Sox10^tm1Weg/Sox10⁺ (blue, N = 27), Rps7^Zma/Rps7⁺ (red, N = 16), and Rps7^Zma/Rps7⁺ Sox10^tm1Weg/Sox10⁺ (yellow, N = 8) (B). (C, D) Adult Rps7^Zma/Rps7⁺ and Rps7^Mtu/Rps7⁺ mutants do not have dark skin in foot pads and tails. (E,F) H&E stained sections through the tail skin of Rps7^Zma/Rps7⁺ mice reveal epidermal (*) and dermal (arrowhead) pigmentation similar to that of wild-type (WT) mice, confirming the presence of melanocytes in the tail.

Copyright

This image is from Watkins-Chow DE, PLoS Genet 2013 Jan;9(1):e1003094, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195156

Associated Alleles

Symbol	Name
Rps7^Zma	ribosomal protein S7; zuma
Sox10^tm1Weg	SRY (sex determining region Y)-box 10; targeted mutation 1, Michael Wegner

Associated Genotypes

Allelic Composition	Genetic Background
Rps7^Zma/Rps7^+ Sox10^tm1Weg/Sox10^+	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeH