Phenotype Image Detail

Image

Caption

Morphology and histology of Cul4b^tm1.1Yxg/Y (KO) embryos. (B) Photomicrographs of E7.5 embryos dissected from surrounding deciduas tissue of the same uterus. The two embryos on the left appear normal in size and morphology and the two on the right were much smaller and were partially deteriorated. The bar represents 200 um. (C) H&E staining of paraffin sections of wild-type (WT) and mutant embryos at 7.5 dpc. Littermate embryos at 7.5 dpc were paraffin embedded and cross sectioned together with their surrounding deciduas. The genotype of each embryo was determined by immunohistochemistry using an anti-Cul4b antibody, as shown below. (D) Immunohistochemistry of paraffin sections of wild-type and mutant embryos at 7.5 dpc with an anti-Cul4b antibody. (E-F) Photomicrographs with higher magnification of the stained section shown in (D).

Copyright

This image is from Jiang B, PLoS One 2012;7(5):e37070, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199139

Associated Alleles

Symbol	Name
Cul4b^tm1.1Yxg	cullin 4B; targeted mutation 1, Yaoqin Gong

Associated Genotypes

Allelic Composition	Genetic Background
Cul4b^tm1.1Yxg/Y	involves: 129X1/SvJ * FVB/N