Phenotype Image Detail

Image

Caption

Morphology and histology of placentas of wild-type (WT), Cul4b^tm1.1Yxg/Cul4b⁺ (Het) and absorbed embryos at 14.5 days post coitum (dpc). (A) Representative photographs of placentas of WT, heterozygous mutant and absorbed embryos at 14.5 dpc. (B) H&E staining of radial sections of placentas. sp, spongiotrophoblast layer; la, labyrinthine layer. Lower panels are the higher magnification of the upper panels. (C) Immunohistochemisty of radial sections of placentas with an antibody to PECAM, an angiogenesis marker. Middle panels are the higher magnification of the upper panels, and lower panels are the higher magnification of the middle panels.

Copyright

This image is from Jiang B, PLoS One 2012;7(5):e37070, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199139

Associated Alleles

Symbol	Name
Cul4b^tm1.1Yxg	cullin 4B; targeted mutation 1, Yaoqin Gong

Associated Genotypes

Allelic Composition	Genetic Background
Cul4b^tm1.1Yxg/Cul4b^+	involves: 129X1/SvJ * FVB/N