Phenotype Image Detail

Image

Caption

Homozygous Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi} (Oxr1^tm1a/tm1a) and bella/bella (bel/bel) mice show a very similar pattern and distribution of terminal deoxynucleotidyltransferase dUTP nick end labeling (TUNEL)-positive (red) in the granule cell layer of the cerebellum at P21 compared with heterozygous Oxr1 (Oxr1^tm1a/+) animals where no cell death was observed. These data are quantified in D. Data are represented as the mean +/-S.E. using one-way ANOVA with Dunnett's multiple comparison test (***, p < 0.001). Scale bars: 1 mm in B and 400 um in C. Higher (2x) magnification is shown in the inset panels.

Copyright

This image is from Finelli MJ, J Biol Chem 2016 Feb 5;291(6):2751-63 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:230923

Associated Alleles

Symbol	Name
bella	bella
Oxr1^tm1a(EUCOMM)Wtsi	oxidation resistance 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Oxr1^tm1a(EUCOMM)Wtsi	oxidation resistance 1; targeted mutation 1a, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
bella/bella	involves: BALB/c * C3H/HeH
Oxr1^tm1a(EUCOMM)Wtsi/Oxr1^tm1a(EUCOMM)Wtsi	C57BL/6N-Oxr1^tm1a(EUCOMM)Wtsi