Phenotype Image Detail

Image

Caption

Tmem178 deletion worsens inflammatory bone loss. Representative microCT 3D reconstructions of calvaria from wild-type and Tmem178^tm1Lex/Tmem178^tm1Lex (Tmem178-/-) mice receiving 100 ug of supracalvarial LPS. n = 10 per genotype. Mutant mice injected with LPS over the calvaria develop profound focal osteolysis. (E) Representative microCT 3D reconstructions of knees from WT and mutant mice after K/BxN serum transfer arthritis. Mutants suffer more bone loss than wild-type mice. n = 10 per genotype.

Copyright

This image is from Decker CE, Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15654-9. Copyright 2015 National Academy of Sciences, U.S.A. J:228311

Associated Alleles

Symbol	Name
Tmem178^tm1Lex	transmembrane protein 178; targeted mutation 1, Lexicon Pharmaceuticals
Tmem178^tm1Lex	transmembrane protein 178; targeted mutation 1, Lexicon Pharmaceuticals

Associated Genotypes

Allelic Composition	Genetic Background
Tmem178^tm1Lex/Tmem178^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6