Phenotype Image Detail

Image

Caption

Alizarin Red/Alcian Blue staining of the skeleton in 25-week-old Tent5a^m1Mhda/Tent5a^m1Mhda (Fam46a^E157*/-) mice. a) Alizarin Red/Alcian Blue staining of the whole skeletons revealed a possible delayed ossification within the mouse tail, snout, and pelvis shown by the extensive blue staining of the cartilage (black arrows). b) The mutant mouse had a smaller skull with a very thin parchment-like calvaria (upper picture). c, d) The scapula and ischium bones showed smaller size and abnormal shapes in the mutant mouse (left homozygous, right WT, black arrows). e) The humeri showed malformations like thickening and twisting in the mutant mouse (left homozygous mutant, right WT, black arrows). f) Magnification of a possible delay in ossification within the mouse tail (left mutant, right WT, black arrows).

Copyright

This image is from Diener S, Mamm Genome 2016 Apr;27(3-4):111-21 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:230816

Associated Alleles

Symbol	Name
Tent5a^m1Mhda	terminal nucleotidyltransferase 5A; mutation 1, Martin Hrabe de Angelis

Associated Genotypes

Allelic Composition	Genetic Background
Tent5a^m1Mhda/Tent5a^m1Mhda	C3HeB/FeJ-Tent5a^m1Mhda