Phenotype Image Detail

Image

Caption

Femora of 32- to 35-week-old wild-type (WT), Tent5a^m1Mhda/Tent5a⁺ (Fam46a^E157*/+), and Tent5a^m1Mhda/Tent5a^m1Mhda (Fam46a^E157*/-) mice were fixed and stained with azan (Heidenhain). The structure of the metaphysis and diaphysis in the trochanteric region of the femur is depicted. Trabeculae (white arrows) of WT and heterozygous mice both in the proximal and distal segments of the growth plate (GP) appear to be quite normal, while in homozygous mutant mice trabeculae are almost completely missing (a-c proximal region, g-i distal region). The architecture of the growth plates is regular in all groups. There is a trend towards enlargement in homozygous mice (f). Cortical bone thickness is unchanged or slightly enhanced in heterozygous compared to control mice (j, k), while in homozygous mutants cortical thickness is reduced (l).

Copyright

This image is from Diener S, Mamm Genome 2016 Apr;27(3-4):111-21 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:230816

Associated Alleles

Symbol	Name
Tent5a^m1Mhda	terminal nucleotidyltransferase 5A; mutation 1, Martin Hrabe de Angelis

Associated Genotypes

Allelic Composition	Genetic Background
Tent5a^m1Mhda/Tent5a^m1Mhda	C3HeB/FeJ-Tent5a^m1Mhda