Phenotype Image Detail

Image

Caption

Regions with abnormal microstructure in Tor1a^tm2Wtd/Tor1a⁺ mice. (A) Three-dimensional display of regions with abnormal white matter microstructure in the mutant animals. Significant reductions (P < 0.0001, Student t test) in fractional anisotropy (FA) were present in the following brain areas: superior cerebellar tract (marked by "1"), subcortical white matter in the primary sensory and motor regions ("2"), caudate/putamen ("3"), pons in the vicinity of the reticular nuclei ("4"), lateral pontomedullary junction ("5"), medial pontomedullary junction ("6"), and white matter adjacent to the superior colliculus ("7"). (B) Two-dimensional displays of these clusters overlaid on a standard mouse MRI template. The color scale represents t values threshold at 3.9 corresponding to P < 0.001 (uncorrected). Individual cluster values for the mutant and for the control groups are represented by box-and-whisker plots. All group differences were highly significant (P < 0.0001).

Copyright

This image is from Ulug AM, Proc Natl Acad Sci U S A 2011 Apr 19;108(16):6638-43. Copyright 2011 National Academy of Sciences, U.S.A. J:171370

Associated Alleles

Symbol	Name
Tor1a^tm2Wtd	torsin family 1, member A (torsin A); targeted mutation 2, William T Dauer

Associated Genotypes

Allelic Composition	Genetic Background
Tor1a^tm2Wtd/Tor1a^+	B6.129S1-Tor1a^tm2Wtd