Phenotype Image Detail

Image

Caption

Connections of the abnormal mutation-related regions visualized by using group tractography. (A and B) Cerebellothalamic (CbT), thalamocortical (TC), and thalamostriatal (TS) pathways reconstructed in the normal and Tor1a^tm2Wtd/Tor1a⁺ (Tor1a^DeltaE/+)) groups. In all three pathways, fewer tracts were visualized in the mutant group relative to the controls. (The thalamic seed volume used for fiber tracking is displayed in blue. For clarity, we displayed only 5% of the tracts in the CbT and TC pathways and 15% of tracts in the TS pathway.) (C and D) Tracts connecting the abnormal pontine and pontomedullary regions with the cerebellum (PCb and PmCb) are also displayed for the two groups. Fewer tracts were also observed in these pathways in the mutant group. P, pontine; Pm, pontomedullary; Cb, cerebellum.

Copyright

This image is from Ulug AM, Proc Natl Acad Sci U S A 2011 Apr 19;108(16):6638-43. Copyright 2011 National Academy of Sciences, U.S.A. J:171370

Associated Alleles

Symbol	Name
Tor1a^tm2Wtd	torsin family 1, member A (torsin A); targeted mutation 2, William T Dauer

Associated Genotypes

Allelic Composition	Genetic Background
Tor1a^tm2Wtd/Tor1a^+	B6.129S1-Tor1a^tm2Wtd