Phenotype Image Detail

Image

Caption

Tracheal malformation in Fstl1^tm1.1Ning/Fstl1^tm1.1Ning (-/-) mice. (A) Transverse sections of the middle portion of trachea from a wild-type (-/-) and two homozygous mice before (E18.5) and after breath (P0) showed an increase in the lumen diameter (asterisk), dispersion and discontinuity of cartilage ring (arrow), and disorganization of the epithelial layer in the mutants. (Scale bars, 100 um.) (B) Alcian blue staining revealed impaired banding pattern of tracheal C-ring cartilage in all mutant skeletal preparations (ventral views). (C). Sections stained with an antibody against type II collagen (arrows). (Scale bars, 100 um.)

Copyright

This image is from Geng Y, Proc Natl Acad Sci U S A 2011 Apr 26;108(17):7058-63. Copyright 2011 National Academy of Sciences, U.S.A. J:171347

Associated Alleles

Symbol	Name
Fstl1^tm1.1Ning	follistatin-like 1; targeted mutation 1.1, Wen Ning

Associated Genotypes

Allelic Composition	Genetic Background
Fstl1^tm1.1Ning/Fstl1^tm1.1Ning	involves: 129S4/SvJae * C57BL/6J * FVB/N