Phenotype Image Detail

Image

Caption

Abnormal lung morphogenesis and lung epithelial cell hyperplasia in Fstl1^tm1.1Ning/Fstl1^tm1.1Ning (-/-) mice. (A) Histological analysis of embryos (E18.5) and newborn pups (P0) revealed normal inflated alveoli with thinner septa in wild-type (+/+), but thickened hypercellular septa with reduced airspaces in the mutants. (Scale bars, 50 um.) (B) Distribution of TTF1 by immunohistochemistry (IHC). (Scale bars, 100 um.) The percentage of the total examined sac area of the lung section or the percentage of the TTF1-positive cells in the total cells of the lung are shown in the top right corner of each diagram (P < 0.05). (C) Quantification of cell proliferation by phosphohistone H3 (p-HH3) immunostaining in E15.5 WT and mutant lungs. The graph represents the mean of four independent experiments showing the comparison of the percentages of p-HH3-positive cells in the epithelium and mesenchyme between WT and mutant lungs.

Copyright

This image is from Geng Y, Proc Natl Acad Sci U S A 2011 Apr 26;108(17):7058-63. Copyright 2011 National Academy of Sciences, U.S.A. J:171347

Associated Alleles

Symbol	Name
Fstl1^tm1.1Ning	follistatin-like 1; targeted mutation 1.1, Wen Ning

Associated Genotypes

Allelic Composition	Genetic Background
Fstl1^tm1.1Ning/Fstl1^tm1.1Ning	involves: 129S4/SvJae * C57BL/6J * FVB/N