Phenotype Image Detail

Image

Caption

Impaired alveolar epithelial cell differentiation/maturation in Fstl1^tm1.1Ning/Fstl1^tm1.1Ning (-/-) lungs. (C) Transmission EM of the lung septa of E18.5 embryos shown at low magnification (LM) and high magnification (HM). Squamous alveolar type I epithelial cells (AEC-I) in wild-type (WT) was closely opposite to densely stained capillary endothelial cell creating thin blood-air barrier (Upper Left). Cuboidal alveolar type II epithelial cells (AEC-II) in WT lungs contained many lamellar bodies (arrows) and apical microvilli (Lower Left). Surfactants (asterisk) were visible in the saccular spaces (Upper Left). The blood-air barrier was significantly thicker with increased numbers of undifferentiated cuboidal epithelial cells in the mutants (Upper Right). These cells were immature with dispersed cytoplasmic glycogen and some small lamellar bodies (arrows; Lower Right). (Scale bars: Upper, 10 um; Lower, 2 um.)

Copyright

This image is from Geng Y, Proc Natl Acad Sci U S A 2011 Apr 26;108(17):7058-63. Copyright 2011 National Academy of Sciences, U.S.A. J:171347

Associated Alleles

Symbol	Name
Fstl1^tm1.1Ning	follistatin-like 1; targeted mutation 1.1, Wen Ning

Associated Genotypes

Allelic Composition	Genetic Background
Fstl1^tm1.1Ning/Fstl1^tm1.1Ning	involves: 129S4/SvJae * C57BL/6J * FVB/N