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Caption | Impaired alveolar epithelial cell differentiation/maturation in Fstl1tm1.1Ning/Fstl1tm1.1Ning (-/-) lungs. (C) Transmission EM of the lung septa of E18.5 embryos shown at low magnification (LM) and high magnification (HM). Squamous alveolar type I epithelial cells (AEC-I) in wild-type (WT) was closely opposite to densely stained capillary endothelial cell creating thin blood-air barrier (Upper Left). Cuboidal alveolar type II epithelial cells (AEC-II) in WT lungs contained many lamellar bodies (arrows) and apical microvilli (Lower Left). Surfactants (asterisk) were visible in the saccular spaces (Upper Left). The blood-air barrier was significantly thicker with increased numbers of undifferentiated cuboidal epithelial cells in the mutants (Upper Right). These cells were immature with dispersed cytoplasmic glycogen and some small lamellar bodies (arrows; Lower Right). (Scale bars: Upper, 10 um; Lower, 2 um.) | ||||
Copyright | This image is from Geng Y, Proc Natl Acad Sci U S A 2011 Apr 26;108(17):7058-63. Copyright 2011 National Academy of Sciences, U.S.A. J:171347 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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