Phenotype Image Detail

Image

Caption

Tracheal malformations in Fstl1^tm1.1Ning/Fstl1^tm1.1Ning mice. (A) Transverse sections of the E18.5 trachea of a wild-type (WT) and two homozygous mice before (E18.5, Left) and after breath (P0, Right) showed an increase in the lumen diameter (asterisk), dispersion and discontinuity of cartilage ring (arrow), and disorganization of the epithelial layer in mutants. (Scale bars, 100 um.) (B) Transverse sections of the middle portion of the trachea of a WT mouse and two homozygous mice. At E13.5, mutant trachea showed a slight enlargement of the lumen. At E15.5, the tracheal malformations were obvious in mutant sections. (Scale bars, 100 um.) (C) The disorganized tracheal epithelial layer of mutant mice at E18.5 contained bigger cells with shorter and disordered cilia, whereas columnar and straightforward ciliated pseudostratified epithelial cells were observed in WT tracheas. (Scale bars, 100 um.)

Copyright

This image is from Geng Y, Proc Natl Acad Sci U S A 2011 Apr 26;108(17):7058-63. Copyright 2011 National Academy of Sciences, U.S.A. J:171347

Associated Alleles

Symbol	Name
Fstl1^tm1.1Ning	follistatin-like 1; targeted mutation 1.1, Wen Ning

Associated Genotypes

Allelic Composition	Genetic Background
Fstl1^tm1.1Ning/Fstl1^tm1.1Ning	involves: 129S4/SvJae * C57BL/6J * FVB/N