Phenotype Image Detail

Image

Caption

Dwarfism, torticollis, scoliosis, osteopenia, and shortened long bones in Slc39a14^tm1Thir/Slc39a14^tm1Thir (KO) mice. (A) Left. Appearance of control (Ctrl) and mutant mice (4-weeks-old). Bar indicates 5 cm. Right. Body weights of 4-week-old control (Ctrl) (male, n = 9; female, n = 9), Mutant (male, n = 10; female, n = 7), and neonatal (control, n = 22; mutant, n = 14) mice. Data represent the mean +/- S.D. (**P<0.01, ***P<0.001). (B) Frontal views (4-week-old) and X-ray radiographs (8-week-old) of a control (Ctrl) and a mutant female mouse. (C) Bone histomorphometric analysis of 4-week-old control (Ctrl) and mutant female mice (n = 5). Data represent the mean +/- S.D. (*P<0.05). (D) X-ray radiographs of the femurs (8-week-old), and the tibial length (6-week-old) of control (Ctrl) and mutant mice (n = 5). Data represent the mean +/- S.D. (***P<0.001).

Copyright

This image is from Hojyo S, PLoS One 2011;6(3):e18059, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171670

Associated Alleles

Symbol	Name
Slc39a14^tm1Thir	solute carrier family 39 (zinc transporter), member 14; targeted mutation 1, Toshio Hirano

Associated Genotypes

Allelic Composition	Genetic Background
Slc39a14^tm1Thir/Slc39a14^tm1Thir	involves: 129 * C57BL/6