Phenotype Image Detail

Image

Caption

Progressive loss of cone photoreceptors in Guca1a^tm1.1Hunt/Guca1a⁺ and Guca1a^tm1.1Hunt/Guca1a^tm1.1Hunt mice, Representative retinal flat mounts taken from 5 month-old mice stained with PNA and anti-cone opsin antibody. There are fewer PNA-positive cone cells present in mutant compared to wild-type (WT) retinae, as well as a fewer opsin-expressing cells in mutant versus WT retinae. Quantitative analysis shows that there are significantly fewer cone ops in expressing cells in mutant retinae than PNA-positive cells, although the labelling of both markers is significantly reduced in heterozygous and homozygous mutant mice as compared to WT littermates. (b) Representative retinal flatmounts taken from 12 month-old mice confirms progression of cone degeneration; in mutant mice, there are fewer opsin-positive cells at 12 months compared to WT littermates.

Copyright

This image is from Buch PK, PLoS One 2011;6(3):e18089, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171667

Associated Alleles

Symbol	Name
Guca1a^tm1.1Hunt	guanylate cyclase activator 1a (retina); targeted mutation 1.1, David M Hunt

Associated Genotypes

Allelic Composition	Genetic Background
Guca1a^tm1.1Hunt/Guca1a^+	involves: 129
Guca1a^tm1.1Hunt/Guca1a^tm1.1Hunt	involves: 129