Phenotype Image Detail

Image

Caption

Progressive loss of substantia nigra dopaminergic neurons in Tg(PDGFB-LRRK2*G2019S)340Djmo/0 transgenic mice. A, Example of TH and Nissl staining in the substantia nigra of non-transgenic (NTG) and Tg(PDGFB-LRRK2*G2019S)340Djmo/0 (G2019S or TG) mice at 19-20 months. B and C, Stereological counts for TH+ and Nissl+ neurons in the pars compacta region of NTG and TG mice at (B) 1-2 months (n = 7-8 mice/genotype) and (C) 19-20 months (n=5 mice/genotype). D, Stereological measurement of TH+ dopaminergic neuritic density in the pars reticulata of NTG or TG mice at 19-20 months, expressed as average length of TH+ fibers (mm) per um³ section area (n = 5-6 mice/genotype).

Copyright

This image is from Ramonet D, PLoS One 2011;6(4):e18568, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171645

Associated Alleles

Symbol	Name
Tg(PDGFB-LRRK2*G2019S)340Djmo	transgene insertion 340, Darren Moore

Associated Genotypes

Allelic Composition	Genetic Background
Tg(PDGFB-LRRK2*G2019S)340Djmo/0	involves: C3H/HeJ * C57BL/6J