Phenotype Image Detail

Image

Caption

Transmission electron microscopic (TEM) analysis of striatal tissue from 17-18 month-old Tg(PDGFB-LRRK2*G2019S)340Djmo/0 (TG) transgenic mice revealing the accumulation of autophagic vacuoles (indicated by *) within (A-B) neuronal soma and (C-D) axonal-rich regions. Nuclei (nuc), axons (ax) and normal mitochondria (m) are indicated. (E) Quantitation of the density of autophagic vacuoles in equivalent regions of striatum from 17-18 month-old transgenic (TG) mice relative to their non-transgenic (NTG) littermates. Bars represent the mean +/- SEM (n = 3 mice/genotype). *P<0.01 comparing TG and NTG mice. Scale bars: 200 nm (A-D).

Copyright

This image is from Ramonet D, PLoS One 2011;6(4):e18568, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171645

Associated Alleles

Symbol	Name
Tg(PDGFB-LRRK2*G2019S)340Djmo	transgene insertion 340, Darren Moore

Associated Genotypes

Allelic Composition	Genetic Background
Tg(PDGFB-LRRK2*G2019S)340Djmo/0	involves: C3H/HeJ * C57BL/6J