Phenotype Image Detail

Image

Caption

H&E or modified Gomori trichrome (mGT) staining of tibialis anterior (TA) muscle from 10-month-old wild-type (WT), Cryab^tm1.1Ady/Cryab⁺ (alphaB-R120G heterozygous), or Cryab^tm1.1Ady/Cryab^tm1.1Ady (alphaB-R120G homozygous) mutant mice. H&E, evidence of myopathy in mutant muscle with small angular fibers (open arrowhead) and internal nuclei (closed arrowhead). mGT, increased dark staining consistent with the accumulation of myofibrillar proteins (arrows) in mutant muscle. Scale bar is 50 um.

Copyright

This image is from Andley UP, PLoS One 2011;6(3):e17671, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171679

Associated Alleles

Symbol	Name
Cryab^tm1.1Ady	crystallin, alpha B; targeted mutation 1.1, Usha P Andley

Associated Genotypes

Allelic Composition	Genetic Background
Cryab^tm1.1Ady/Cryab^tm1.1Ady	involves: 129X1/SvJ * C57BL/6 * C57BL/6J
Cryab^tm1.1Ady/Cryab^+	involves: 129X1/SvJ * C57BL/6 * C57BL/6J