Phenotype Image Detail

Image

Caption

The Axin2^canp/Axin2^canp (canp) mutant heart phenotype. (A-C) Scanning electron micrographs (SEM) show the abnormal heart morphology of mutant embryos at E9.5, in contrast to the wild-type (wt) embryos (A) with a single heart tube and well-defined left ventricle (LV), right ventricle (RV), and outflow tract (OFT). From a total of 135 mutants scored, 40% showed cardia bifida, with all chambers duplicated (B), 37% showed partial cardia bifida, and 23% had one enlarged heart tube with a continuous ridge of cells marking the interface between the left and right cardiac primordia (arrow in C). The remaining mutants had a well-formed LV but slightly shortened OFT/RV with prominent bulges (data not shown). (Scale bar, 40 um.) (D-F) Hematoxylin and eosin-stained cross-sections of E9.5 embryos. WT hearts developed RV, LV, and atrium (D). Section through mutants like the one in B, showing two hearts with two LVs (E). (F) Section through the dilated OFT/RV of an embryo like the one shown in C. Despite the morphological defects, both cardiac jelly and trabeculae were well formed in the mutants.

Copyright

This image is from Qian L, Proc Natl Acad Sci U S A 2011 May 24;108(21):8692-7. Copyright 2011 National Academy of Sciences, U.S.A. J:171894

Associated Alleles

Symbol	Name
Axin2^canp	axin 2; canopus

Associated Genotypes

Allelic Composition	Genetic Background
Axin2^canp/Axin2^canp	C3.B6-Axin2^canp