Phenotype Image Detail

Image

Caption

Anterior visceral endoderm (AVE) defects in Hhex^tm1.1Tmj/Hhex⁺ (Hexd activated) embryos. (A) Lefty1/2, (B) Fz8, (C) Cerl, (D) Sfrp5, (E) Dkk1 and (F) Ttr expression in control and mutant embryos at 6.5dpc. Mutant embryos with reduced or lost expression in the AVE = Lefty1/2 n = 13/28; Fz8 n = 4/13; Cerl, n = 7/16; Sfrp5, n = 2/14; Dkk1, n = 0/15; Ttr normal in n = 16/16; Lefty1/2 (L1 and L2) lost from the posterior epiblast in n = 7/28. Scale bar 90 um.

Copyright

This image is from Stuckey DW, PLoS One 2011;6(3):e17620, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171680

Associated Alleles

Symbol	Name
Hhex^tm1.1Tmj	hematopoietically expressed homeobox; targeted mutation 1.1, Thomas M Jessell

Associated Genotypes

Allelic Composition	Genetic Background
Hhex^tm1.1Tmj/Hhex^+	involves: 129S1/Sv * FVB/N