Phenotype Image Detail

Image

Caption

Defective primitive streak formation in Hhex^tm1.1Tmj/Hhex⁺ (Hexd activated) mutants. (A-C) Eomes, T and Cripto expression in wild-type (WT) and mutant embryos at 6.5dpc. (D-N) Expression of Eomes, T, Chordin, Noggin, Foxa2, Wnt3, Tbx6, Fgf8, Snail, Sox17 and Cerl in control and mutant embryos at 7.5dpc. Mutant embryos with normal expression: T (6.5dpc) n = 7/7; Cripto n = 9/9 Wnt3 n = 11/11; Tbx6 n = 13/13; Foxa2 n = 8/8; Cerl n = 14/14; Sox17 n = 14/14. Mutant embryos with reduced or lost expression Eomes (6.5dpc) n = 2/11; Eomes (7.5dpc) n = 3/18; T (7.5dpc) n = 3/14; Chordin n = 2/11; Noggin n = 6/15, Fgf8 n = 5/17; Snail n = 3/14. Blue arrow indicates the anterior primitive streak in D and E. Scale bar 90 um.

Copyright

This image is from Stuckey DW, PLoS One 2011;6(3):e17620, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171680

Associated Alleles

Symbol	Name
Hhex^tm1.1Tmj	hematopoietically expressed homeobox; targeted mutation 1.1, Thomas M Jessell

Associated Genotypes

Allelic Composition	Genetic Background
Hhex^tm1.1Tmj/Hhex^+	involves: 129S1/Sv * FVB/N