Phenotype Image Detail

Image

Caption

Loss of function of Synj2 leads to cochlear hair cell loss. Ultrastructural analysis using scanning electron microscopy of cochlear hair cells in Synj2^mozart/Synj2^mozart (Synj2^N538K/^N538K) and wild-type (Synj2^+/+) mice. Apical, mid and basal cochlear turns were examined at 2, 4, 8 and 12 weeks of age. As early as 2 weeks of age, signs of hair cell degeneration are seen in outer hair cells of the basal cochlear turn (Panel D). At 4 weeks, the majority of basal outer hair cells appear sunken with fused stereocilia (Panel H). Mid cochlear inner hair cells show stereocilia fusion at 8 weeks (Panel L). Fused stereocilia or complete loss of hair bundles is common in mid region outer hair cells at 12 weeks (Panel P). Panel T shows the structure of a normal outer hair cell. OHC, outer hair cells; IHC, inner hair cells. Scale bar: 4 um.

Copyright

This image is from Manji SS, PLoS One 2011;6(3):e17607, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171701

Associated Alleles

Symbol	Name
Synj2^mozart	synaptojanin 2; mozart

Associated Genotypes

Allelic Composition	Genetic Background
Synj2^mozart/Synj2^mozart	C57BL/6-Synj2^mozart