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Phenotype Image Detail
Image
Caption Electron micrograph images of aortas from 12- to 14-month-old animals expressing the R1031C mutation, Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/Gt(ROSA)26Sor+ Tg(Tagln-cre)1Her/0 (CADASIL), (B) show thinner layers of vascular smooth muscle cells (vSMCs) compared with controls (A).
Copyright This image is from Arboleda-Velasquez JF, Proc Natl Acad Sci U S A 2011 May 24;108(21):E128-35. Copyright 2011 National Academy of Sciences, U.S.A. J:171887
Associated
Alleles
Symbol Name
Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Spyros Artavanis-Tsakonas
Tg(Tagln-cre)1Her transgene insertion 1, Joachim Herz
Associated
Genotypes
Allelic Composition Genetic Background
Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/Gt(ROSA)26Sor+
Tg(Tagln-cre)1Her/0 		involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory