Phenotype Image Detail

Image

Caption

(A) MRI was used to assess tumor progression in the liver. H&E images of the liver from Notch1^tm3(cre)Rko/Notch1⁺ (N1::Cre^lo/+) and Notch1^tm3(cre)Rko/Notch1^tm2Rko (N1::Cre^lo/fl) are also shown. Scale bar: 100 um. (B) Bioluminescence imaging of live animals and freshly dissected organs at the specified ages. Shown are mean and SD of organ luciferase signal (10⁵ photons/s) from at least 4 different individuals of the same genotype. Organs showing statistically significant differences in signal intensity are boxed in red.

Copyright

This image is from Liu Z, J Clin Invest 2011 Feb 1;121(2):800-8 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171829

Associated Alleles

Symbol	Name
Notch1^tm2Rko	notch 1; targeted mutation 2, Raphael Kopan
Notch1^tm3(cre)Rko	notch 1; targeted mutation 3, Raphael Kopan

Associated Genotypes

Allelic Composition	Genetic Background
Notch1^tm2Rko/Notch1^tm3(cre)Rko	involves: 129X1/SvJ * C57BL/6