Phenotype Image Detail

Image

Caption

Thrombotic microangiopathy in Ehd3^tm1.2Haba/Ehd3^tm1.2Haba Ehd4^tm1.1Haba/Ehd4^tm1.1Haba mice. (A-B) Kidney sections from 22 day old Ehd3^tm1.2Haba/Ehd3^tm1.2Haba Ehd4^tm1.1Haba/Ehd4^tm1.1Haba (Ehd3-/-;Ehd4-/-) mice and littermate controls were stained with PAS to visualize tubular and glomerular basement membranes. Healthy capillary loops are seen in the control glomeruli (panel A) while mutant kidney sections showed endothelial swelling (e), enlarged glomeruli with segmental thickening (t), duplication of basement membranes (d) and mesangiolysis (m). Some tubular dilation is also seen (asterisks). (C-D) Jones methenamine silver (JMS) staining of kidney sections from double homozygous mutant mice (panel D) and littermate controls (panel C) show duplicated and thickened glomerular basement membrane, expanded mesangium and relatively avascular glomeruli in the double homozygous mutant sections. Thick black arrows point to glomeruli.

Copyright

This image is from George M, PLoS One 2011;6(3):e17838, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171715

Associated Alleles

Symbol	Name
Ehd3^tm1.2Haba	EH-domain containing 3; targeted mutation 1.2, Hamid Band
Ehd4^tm1.1Haba	EH-domain containing 4; targeted mutation 1.1, Hamid Band

Associated Genotypes

Allelic Composition	Genetic Background
Ehd3^tm1.2Haba/Ehd3^tm1.2Haba Ehd4^tm1.1Haba/Ehd4^tm1.1Haba	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J