Phenotype Image Detail

Image

Caption

Ultrastructural changes in Ehd3^tm1.2Haba/Ehd3^tm1.2Haba Ehd4^tm1.1Haba/Ehd4^tm1.1Haba (Ehd3-/-;Ehd4-/-) glomeruli. (A) Endothelial cells with fenestrations (black arrow heads) and podocytes with intact foot processes (white arrows) are evident in the control section. (Ai) Inset shows a representative higher magnification image, inset scale bar = 500 nm. (B) Abnormally thickened and lamellated basement membranes (t), swollen endothelium without fenestrations and effacement of podocytes foot processes were seen in the double homozygous mutant kidney section. Multiple small "holes" presumed to be abnormal endosomes were seen in the endothelium (black arrows); these structures are clear in the higher magnification image in B. Inset scale bar = 500 nm. Scale bars = 2 mm. (C-D) Images from control kidneys also show additional changes including mesangiolysis (m), mesangial interposition (i), flocculent subendothelial material (f) and platelet (p) accumulation in a capillary loop. GBM, glomerular basement membrane. Scale bars = 5 um.

Copyright

This image is from George M, PLoS One 2011;6(3):e17838, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171715

Associated Alleles

Symbol	Name
Ehd3^tm1.2Haba	EH-domain containing 3; targeted mutation 1.2, Hamid Band
Ehd4^tm1.1Haba	EH-domain containing 4; targeted mutation 1.1, Hamid Band

Associated Genotypes

Allelic Composition	Genetic Background
Ehd3^tm1.2Haba/Ehd3^tm1.2Haba Ehd4^tm1.1Haba/Ehd4^tm1.1Haba	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J