Phenotype Image Detail

Image

Caption

(E-L) TUNEL staining of sagittal sections from control and Six1^tm1Mair/Six1^tm1MairEya1^tm1Rilm/Eya1^tm1Rilm revealed increased cell death in pharyngeal endoderm, SHF/splanchnic mesoderm (SHF/SpM), and pharyngeal mesenchyme (PM) that contained cardiac neural crest cells (CNCs) and mesoderm. Boxed regions in E-G are enlarged in H-J. Original magnification, x200 (A, B, and E-J). n = 3. P values were determined by Student's t test.

Copyright

This image is from Guo C, J Clin Invest 2011 Apr 1;121(4):1585-95 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172023

Associated Alleles

Symbol	Name
Eya1^tm1Rilm	EYA transcriptional coactivator and phosphatase 1; targeted mutation 1, Richard Maas
Six1^tm1Mair	sine oculis-related homeobox 1; targeted mutation 1, Pascal Maire

Associated Genotypes

Allelic Composition	Genetic Background
Eya1^tm1Rilm/Eya1^tm1Rilm Six1^tm1Mair/Six1^tm1Mair	involves: 129S1/Sv * 129X1/SvJ * C57BL/6