Phenotype Image Detail

Image

Caption

F, S.E. images from age P13 mice show disorganization of the outer rod segment (OS) in Mfsd2a^tm1Dls/Mfsd2a^tm1Dls (KO) mice and retinal pigment epithelium (RPE) appears swollen. Scale bar, 2 um. The middle panel shows that villi of mutant RPE appear thickened and interspersed with OS that are not formed properly relative to those seen in wild-type (WT) (white arrow). Scale bar, 2 um. The far right panel is of the basal membrane of the RPE, where edema was also seen at the basal infoldings of mutant RPE but not in WT RPE (yellow arrow). Scale bar, 1 um. G, immunolocalization of ezrin was performed on eye sections taken from P13 and 5-month-old mice. At age P13, mutant villi appears disorganized and collapsed onto itself at 5 months of age (white arrows). Scale bar, 20 um. P13, n = 3 per genotype. INL, inner nuclear layer; IS, inner segment; PR, photoreceptor; AM, apical membrane; BI, basal infoldings.

Copyright

This image is from Wong BH, J Biol Chem 2016 May 13;291(20):10501-14 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:234197

Associated Alleles

Symbol	Name
Mfsd2a^tm1Dls	MFSD2 lysolipid transporter A, lysophospholipid; targeted mutation 1, David L Silver

Associated Genotypes

Allelic Composition	Genetic Background
Mfsd2a^tm1Dls/Mfsd2a^tm1Dls	B6.Cg-Mfsd2a^tm1Dls