Phenotype Image Detail

Image

Caption

Histology of growth plate cartilage from wild-type, Col2a1^Rgsc856/Col2a1⁺ (hetero), and Col2a1^Rgsc856/Col2a1^Rgsc856 (homo) mutants at E19.5. A-C) Hematoxylin & eosin (HE)-stained sections of the growth plate cartilage. The boxed regions (a, b, and c) represent the resting, proliferating, and hypertrophic zones, respectively. Magnified views of the boxed regions are shown in the same columns. D-F) Toluidine blue-stained sections of the proliferating zone of the growth plate cartilage. Note that the total length of the growth plate cartilage was drastically reduced in the homozygotes (C). The typical columnar alignment of proliferating chondrocytes was observed in wild-type mice (Ab) but became disordered in the heterozygotes (Bb). This alignment was completely lost in the homozygotes (Cb). Weak staining by toluidine blue was evident in the homozygotes (F). Scale bars 50 um (A-C) and 10 um (Aa-Cc and D-F).

Copyright

This image is from Furuichi T, Mamm Genome 2011 Jun;22(5-6):318-28 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:171906

Associated Alleles

Symbol	Name
Col2a1^Rgsc856	collagen, type II, alpha 1; RIKEN Genomic Sciences Center (GSC), 856

Associated Genotypes

Allelic Composition	Genetic Background
Col2a1^Rgsc856/Col2a1^+	involves: C57BL/6JJcl * DBA/2JJcl
Col2a1^Rgsc856/Col2a1^Rgsc856	involves: C57BL/6JJcl * DBA/2JJcl