Phenotype Image Detail

Image

Caption

Electron microscope images of the extracellular matrix (ECM) and chondrocytes from the proliferating zone in wild-type, Col2a1^Rgsc856/Col2a1⁺ (hetero) and Col2a1^Rgsc856/Col2a1^Rgsc856 (homo) mice at E18.5. A-C) The images of the ECM are shown. Arrows indicate the proteoglycan aggregates. D-F) The images of the chondrocytes are shown. Arrows show abnormally expanded rough endoplasmic reticulum (ER). Note that the collagen fibers of the homozygotes are markedly reduced (C). Abnormally expanded rough ER was found in the heterozygotes (E) and homozygotes (F). More expanded rough ER was evident in the homozygotes. Scale bars 1 um (A-C) and 2 um (D-F)

Copyright

This image is from Furuichi T, Mamm Genome 2011 Jun;22(5-6):318-28 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:171906

Associated Alleles

Symbol	Name
Col2a1^Rgsc856	collagen, type II, alpha 1; RIKEN Genomic Sciences Center (GSC), 856

Associated Genotypes

Allelic Composition	Genetic Background
Col2a1^Rgsc856/Col2a1^+	involves: C57BL/6JJcl * DBA/2JJcl
Col2a1^Rgsc856/Col2a1^Rgsc856	involves: C57BL/6JJcl * DBA/2JJcl